Microbial Immunology Laboratory (Assoc. Prof. Jan Dobeš, Ph.D.)












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            The Microbial Immunology Laboratory, led by Assoc. Prof. Jan Dobeš at the Faculty of Scien
            University, focuses on the complex interactions between the immune system and microbes. Th
            research provides key insights into how the human immune system recognizes and regulates m

            from commensal gut bacteria to pathogenic yeasts.

            Dr. Dobeš and his team have discovered a new type of immune cells that play a crucial role

            defense against fungal infections and in maintaining the delicate balance between immune p
            and tolerance to the intestinal microbiota. Their findings significantly expand our unders

            immune regulation mechanisms and may open new avenues for therapies targeting autoimmune a
            diseases.


            The group maintains strong international collaborations, including with the Weizmann Insti
            in Israel, and publishes in leading journals such as Nature Reviews Immunology.


            “Research into rare diseases has led us to discoveries that reveal the fundamental princip
            immune system works,” says Jan Dobeš.


            Assoc. Prof. Jan Dobeš is a recipient of the ERC CZ grant and laureate of the ABB Inventio
            Head 2024).


            In addition to his research, he is actively involved in teaching immunology and mentoring 
            generation of scientists.




            Photo: Petr Jan Juračka, archive of Jan Dobeš