Laboratory of Intercellular Communication (Dr. Jan Mašek)












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            Jan Mašek is a developmental biologist studying the interplay of signaling pathways in mam

            development and disease.

            His laboratory focuses on how the Wnt/?-catenin and Notch pathways coordinate cell behavio

            morphogenesis.

            Using advanced mouse genetic models, the team aims to uncover the mechanisms linking devel

            with human disorders such as Alagille syndrome and biliary atresia.


            Jan Mašek earned his Ph.D. from Charles University after conducting his doctoral research 
            of Molecular Genetics of the Czech Academy of Sciences, where he identified one of the key
            determining forebrain identity during development. He then completed a postdoctoral fellow

            Karolinska Institutet in Stockholm in the laboratory of Emma R. Andersson, studying the sp
            Notch ligands in liver development and disease. He is a recipient of the prestigious Sheil
            Postdoctoral Fellowship (EASL), which enabled him to elucidate the specific fibrotic respo

            liver tissue in a mouse model of Alagille syndrome.
            Since 2021, he has led a research group at the Faculty of Science, Charles University, and
            investigator of GAČR, PRIMUS, and Inter-Excellence II projects supporting collaboration of

            researchers from Finland, Israel, Germany, and elsewhere. As chair of the Junior Faculty o
            promotes an open and international academic culture.


            Learn more: www.maseklab.org [ URL "https://www.maseklab.org"]