Jan Mašek is a developmental biologist studying the interplay of signaling pathways in mammalian development and disease.
His laboratory focuses on how the Wnt/β-catenin and Notch pathways coordinate cell behavior and organ morphogenesis.
Using advanced mouse genetic models, the team aims to uncover the mechanisms linking developmental biology with human disorders such as Alagille syndrome and biliary atresia.
Dr. Jan Mašek
Jan Mašek earned his Ph.D. from Charles University after conducting his doctoral research at the Institute of Molecular Genetics of the Czech Academy of Sciences, where he identified one of the key factors determining forebrain identity during development. He then completed a postdoctoral fellowship at the Karolinska Institutet in Stockholm in the laboratory of Emma R. Andersson, studying the specificity of Notch ligands in liver development and disease. He is a recipient of the prestigious Sheila Sherlock Postdoctoral Fellowship (EASL), which enabled him to elucidate the specific fibrotic response of neonatal liver tissue in a mouse model of Alagille syndrome.
Since 2021, he has led a research group at the Faculty of Science, Charles University, and is the principal investigator of GAČR, PRIMUS, and Inter-Excellence II projects supporting collaboration of his teams with researchers from Finland, Israel, Germany, and elsewhere. As chair of the Junior Faculty organization, he promotes an open and international academic culture.
Learn more: www.maseklab.org
Biocentre is financially supported by the National Restoration Plan; Investment identification number: Z332802000005.
